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This weekend marks the five year anniversary of the crash of Comair Flight 5191. Forty-nine people were killed when the plane took off from the wrong…

The Oscar-nominated actress, who has appeared in Up in the Air and The Departed, talks about her directorial debut, a film about a woman's search for faith. Farmiga, who calls herself a "seeker," also stars in the film.

Robert Siegel gets a profile on Hurricane Irene from Bill Read, director of the National Hurricane Center.

One of Moammar Gadhafi's last major strongholds in Tripoli has fallen to rebel forces. Among the survivors of the ferocious street fighting are prisoners from the Abu Salim prison, some of whom have been jailed for more than two decades.

Pieces of twisted metal and scrap wood left behind by a massive tornado that tore through Joplin, Mo., are now sitting in a gallery in Kansas City. The sculptures and paintings from the wreckage are to be sold at auction Saturday.

The massive New Madrid earthquakes of 1811 and 1812 were strong enough to make the Mississippi River run backward. Now, 200 years later, seismologists and geologists are studying the region to assess the likelihood of another huge quake.

One of the largest and potentially most damaging hurricanes to hit the East Coast in decades is heading slowly north. The storm is expected to pass right over New York City and into New England later this weekend. At least four storm-related deaths have been reported, and more than 630,000 homes and businesses are without power.

The Obama administration is considering several new ideas to help shore up the struggling housing market. As first reported by The New York Times this week, one proposal would allow homeowners with government-backed mortgages to refinance them at the current, lower interest rates. Host Scott Simon talks with Columbia University's Christopher Mayer, who helped introduce the mortgage refinancing proposal in 2008.

Hurricane Irene has reached the coast of North Carolina, bringing heavy rains and winds of 85 miles per hour. But there IS some good news. The storm is turning out to be less powerful than forecasters expected. Host Scott Simon talks with NPR science reporter John Hamilton about the latest on Hurricane Irene.

Insurance companies are expecting to be inundated with calls from policyholders reporting damage from the hurricane. With the storm on track to hit densely populated areas where property values are high, the cost of insured losses could be in the billions.