El-Sayed's campaign tested how an antiestablishment candidate on the left would fare in a perennial Midwest battleground. With the win, he'll become the first Muslim American to serve in the Senate.
Among the sweeping victories by Democrats on Tuesday were wins in several congressional districts that Republicans had redrawn explicitly to boost their party ahead of the midterms.
Jeffries, who addressed supporters after House control was called for Democrats, argued voters have sent Congress a message to end extremism and "corruption."